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Since radial chromosomes have multiple centromeres, they can thwart normal chromosome segregation. Figure 4. Figure 3.

EMBO J 29 : — Escort Chanda, deletion of the OD domain, which has been implicated in synapsis in V D J recombination, also diminished the rate of telomere fusions Fig.

Escort Chanda 7. The joining of dysfunctional telomeres was the first of the three Escort Chanda c-NHEJ Escort Chanda where a striking dependency on 53BP1 was observed Dimitrova et al. In G1, deprotected telomeres behave like one-ended DSBs, analogous to a reversed replication fork in S phase.

PARP1 is required for the Escort Chanda of single-stranded breaks SSBs that result from oxidative damage and are formed during base excision repair BER Barnes and Lindahl ; Ray Chaudhuri and Nussenzweiga pathway that removes thousands Escort Chanda aberrant nucleotides per genome each day Fig. Escort Chanda Escort Chanda 70 : — Nat Cell Biol 12 : — Nat Cell Escort Chanda 19 : 1 — 9. Adv Immunol : Escort Chanda —

SSA is a dangerous repair pathway in genomes with many repetitive sequences, since deletions will be a frequent outcome.

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Science : 92 — In the absence of 53BP1, CSR is severely impaired and the recombination in the Ig locus shifts to intraswitch repair events that are accompanied by extensive resection Franco et al. The two predominant DSB repair pathways in mammalian cells.
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A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus. Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells. Mol Cell 18 : — A Schematic of human Escort Chanda. Ganduri SLue NF. Multiple roles for MRE11 Escort Chanda uncapped telomeres.